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Those who have considered having naloxone on-hand because there is a chance they might need it to help someone who has overdosed have a new reason to keep it available.
Ohio's Department of Public Safety issued a warning last week about new substances that have entered the state's drug supply.
According to a report by WSYX, the Ohio Narcotics Intelligence Center says the first problem is the arrival of orphine analogs -- synthetic opioids. These mimic the effects of drugs such as morphine and fentanyl and can disrupt breathing and impact the central nervous system.
The second is use of synthetic veterinary sedatives medetomidine and xylazine. Beyond simply not being for human use, these can create a level of sedation that induces life-threatening effects.
"The drug landscape is always evolving and currently contains dangerous and unpredictable polydrug mixtures. People may think they are taking one substance, when it could be something else entirely, something much more dangerous and potentially fatal," Ohio Department of Public Safety Deputy Chief of Staff Cynthia Peterman said, according to WSYX.
But what can we do?
Aside from spreading the word about these dangers, officials also advise that if you encounter someone you suspect is overdosing, call 911, administer naloxone and stay with the person until emergency medical personnel arrive.
"Naloxone is safe and should be used in the event of a suspected overdose," the Ohio Narcotics Intelligence Center says.
Don't stay quiet. Don't be unprepared.
The monsters who continue to supply Ohio with deadly drugs continue to up their game. The rest of us must, as well.