PEOPLE’S PHARMACY: The confusing history of hormone replacement therapy
Women contemplating hormone replacement therapy to ease hot flashes, night sweats and other miseries of menopause might be feeling confused. Controversy has followed Premarin, one of the dominant brands of replacement estrogen, throughout its history of more than 80 years. Few drugs have lasted as long or seen such extreme swings in popularity. The conjugated estrogens in Premarin are made from pregnant mares’ urine. We suspect that is the origin of the brand name. Premarin grew in popularity from the post-war years through the 1960s (when “Feminine Forever” was a bestselling ...