The nation's longest winning streak ended at 17.
ST. LOUIS -- Marque Perry scored five of his 25 points in the final 13 seconds, and maneuvered inside for the game-winning layup with 3.2 seconds to go as Saint Louis upset second-ranked Louisville 59-58 Wednesday night.
The Billikens (9-12, 3-7) were coming off a pair of road losses to middle-of-the-road Conference USA teams, making them an unlikely team to put an end to the nation's longest winning streak. Louisville (18-2, 8-1 C-USA) had won 17 in a row since a two-point loss to Purdue on Nov. 30 in the second game of the season.
Reece Gaines scored a season-high 28 points for the Cardinals, who have been beating their opponents by an average of 19 points. That also was the margin of victory in the first meeting between the teams at Louisville on Jan. 11, a 73-54 victory.
No. 4 Florida 74, Mississippi 55
GAINESVILLE, Fla. -- Danish superstar Christian Drejer played his best game of the season, finishing with 11 points and five assists, as fourth-ranked Florida turned a two-point game into a blowout.
Drejer made a 3-pointer and had four pretty assists during a 23-3 second-half.
No. 7 Pittsburgh 82,West Virginia 46
PITTSBURGH -- Donatas Zavackas came out of a shooting slump with 15 points and No. 7 Pittsburgh finally played a runaway game after a succession of close ones.
The Panthers (17-3, 7-2 Big East) fell from No. 2 to 7 in the AP poll while dropping road games against Syracuse and Notre Dame, but they never were challenged by the smaller and less physical Mountaineers.
Pittsburgh's 36-point margin of victory was its largest in the 164-game rivalry, topping its 27-point win (92-65) last season in the final game in Fitzgerald Field House.
No. 12 Creighton 70,SW Missouri St. 67, OT
OMAHA, Neb. -- Brody Deren's inside basket gave Creighton the lead and then Michael Lindeman made two free throws with 2.3 seconds left as the 12th-ranked Bluejays came back from a 15-point deficit.
Creighton (22-2, 12-1 Missouri Valley Conference) won its 14th straight home game, despite playing the extra period without leading scorer Kyle Korver, who fouled out in the final minute of regulation after keying the Bluejays' comeback.
No. 13 Oklahoma St. 77,Nebraska 70
LINCOLN, Neb. -- Victor Williams scored 11 of his 25 points during a key second-half run to lead No. 13 Oklahoma State.
Oklahoma State (19-3, 8-1 Big 12) trailed 30-25 at halftime but took the lead at 34-32 when Melvin Sanders threw an inbounds pass off the back of a Nebraska player, retrieved the ball and made a layup.
Texas A & amp;M 73, No. 21 Missouri 71
COLLEGE STATION, Texas -- Bernard King scored a season-high 29 points and Bradley Jackson scored the go-ahead basket with 2 seconds to play.
The Aggies (12-8, 4-5 Big 12) beat a ranked opponent for the first time since Jan. 23, 2001 when they defeated No. 24 Texas 80-74.
Missouri's Travon Bryant hit a 3-point basket from the top of the key to tie the score at 71 with 23 seconds to play. Jackson then drove to the basket and lofted a short jumper over a crowd of Tigers to give the Aggies the win.
No. 16 Maryland 74, Florida St. 72
TALLAHASSEE, Fla. -- Steve Blake scored Maryland's final seven points, including four free throws in the final 17.5 seconds, as the Terrapins rebounded from two straight losses with a victory at Florida State.
Blake, who finished with 15 points, made a 3-pointer to break a 67-67 tie and then clinched the win with his clutch free throws.
Florida State (11-10, 2-8 Atlantic Coast Conference) got within a point at 70-69 on Todd Galloway's layup with 17.5 seconds left and Blake was fouled on the inbounds pass before any time could go off the clock.
No. 11 Marquette 73, DePaul 60
ROSEMONT, Ill. -- Steve Novak scored a career-high 17 points, including four straight 3-pointers during a decisive second-half stretch, as Marquette beat DePaul.
Novak finished with five 3-pointers, topping his career high by two. Chicago native Dwyane Wade added 17 points, eight assists, seven rebounds and three steals for the Golden Eagles (18-3, 9-1 Conference USA), who won their 10th straight.